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SEGURA LAB

ENGINEERING CELL INSTRUCTIVE MATERIALS


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For curmplete list of publications go here


61. Sideris E, Griffin DR, Ding Y, Li S, Weaver WM, Di Carlo D, Hsiai T, Segura T. Particle Hydrogels Based on Hyaluronic Acid Building Blocks ACS Biomat Sci. Eng. 2016 Sept 7; 2(11):2034-2041.


60. Nih LR, Moshayedi P, Llorente IL, Berg AR, Cinkornpumin J, Lowry WE, Carmichael ST,  Segura T. Engineered HA hydrogel for stem cell transplantation in the brain: Biocompatibility data using a design of experiment approach. Data Brief. 2016 Nov 24;10:202-209.


59. Li J, Zhang L, Liu Y, Wen J, Wu D, Xu D, Segura T, Jin J, Lu Y, Wang H. An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules. Chem Commun (Camb). 2016 Nov 15;52(93):13608-13611.


58. Moshayedi P, Nih LR, Llorente IL, Berg AR, Cinkornpumin J, Lowry WE, Segura T, Carmichael ST. Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain. Biomaterials. 2016 Oct;105:145-55.


57. Zhu X, Gojgini S, Chen TH, Teng F, Fei P, Dong S, Segura T, Ho CM. Three dimensional tubular structure self-assembled by vascular mesenchymal cells at stiffness interfaces of hydrogels. Biomed Pharmacother. 2016 Oct;83:1203-1211.


56. Darling NJ, Hung YS, Sharma S, Segura T. Controlling the kinetics of thiol-maleimide Michael-type addition gelation kinetics for the generation of homogenous poly(ethylene glycol) hydrogels. Biomaterials. 2016 Sep;101:199-206.


55. Nih LR, Carmichael ST, Segura T. Hydrogels for brain repair after stroke: an emerging treatment option. Curr Opin Biotechnol. 2016 Aug;40:155-63.


54. Escuin-Ordinas H, Li S, Xie MW, Sun L, Hugo W, Huang RR, Jiao J, de-Faria FM, Realegeno S, Krystofinski P, Azhdam A, Komenan SM, Atefi M, Comin-Anduix B, Pellegrini M, Cochran AJ, Modlin RL, Herschman HR, Lo RS, McBride WH, Segura T, Ribas A. Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors. Nat Commun. 2016 Aug 1;7:12348.


53. Stavrakis AI, Zhu S, Hegde V, Loftin AH, Ashbaugh AG, Niska JA, Miller LS, Segura T, Bernthal NM. In Vivo Efficacy of a "Smart" Antimicrobial Implant Coating. J Bone Joint Surg Am. 2016 Jul 20;98(14):1183-9.


52. Zhu S, Segura T. Cell-Demanded VEGF Release via Nanocapsules Elicits Different Receptor Activation Dynamics and Enhanced Angiogenesis. Ann Biomed Eng. 2016 Jun;44(6):1983-92.


51. Lesher-Perez SC, Segura T, Moraes C. Getting there is half the battle: recent advances in delivering therapeutics. Integr Biol (Camb). 2016 Jan;8(1):8-11.


50. Cam C, Zhu S, Truong NF, Scumpia PO, Segura T. Systematic evaluation of natural scaffolds in cutaneous wound healing. J Mater Chem B Mater Biol Med. 2015 Oct 28;3(40):7986-7992.


48. Boehnke N, Cam C, Bat E, Segura T, Maynard HD. Imine Hydrogels with Tunable Degradability for Tissue Engineering. Biomacromolecules. 2015 Jul 13;16(7):2101-8.


47. Griffin DR, Weaver WM, Scumpia PO, Di Carlo D, Segura T. Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks. Nat Mater. 2015 Jul;14(7):737-44.


46. Tokatlian T, Cam C, Segura T. Porous hyaluronic acid hydrogels for localized nonviral DNA delivery in a diabetic wound healing model. Adv Healthc Mater. 2015 May;4(7):1084-91.


45. Lam J, Carmichael ST, Lowry WE, Segura T. Hydrogel design of experiments methodology to optimize hydrogel for iPSC-NPC culture. Adv Healthc Mater. 2015 Mar 11;4(4):534-9.


44. Lam J, Lowry WE, Carmichael ST, Segura T. Delivery of iPS-NPCs to the Stroke Cavity within a Hyaluronic Acid Matrix Promotes the Differentiation of Transplanted Cells. Adv Funct Mater. 2014 Nov 26;24(44):7053-7062.


43. Du J, Jin J, Liu Y, Li J, Tokatlian T, Lu Z, Segura T, Yuan XB, Yang X, Lu Y. Gold-nanocrystal enhanced bioluminescent nanocapsules. ACS Nano. 2014 Oct 28;8(10):9964-9.


42. Nowak-Sliwinska P, Segura T, Iruela-Arispe ML. The chicken chorioallantoic membrane model in biology, medicine and bioengineering. Angiogenesis. 2014 Oct;17(4):779-804.


41. Zhu S, Segura T. Hydrogel-based nanocomposites of therapeutic proteins for tissue repair. Curr Opin Chem Eng. 2014 May 1;4:128-136.


40. Lam J, Truong NF, Segura T. Design of cell-matrix interactions in hyaluronic acid hydrogel scaffolds. Acta Biomater. 2014 Apr;10(4):1571-80.


39. Griffin DR, Borrajo J, Soon A, Acosta-Vélez GF, Oshita V, Darling N, Mack J, Barker T, Iruela-Arispe ML, Segura T. Hybrid photopatterned enzymatic reaction (HyPER) for in situ cell manipulation. Chembiochem. 2014 Jan 24;15(2):233-42.


38. Cam C, Segura T. Chemical sintering generates uniform porous hyaluronic acid hydrogels. Acta Biomater. 2014 Jan;10(1):205-13.


37. Tokatlian T, Cam C, Segura T. Non-viral DNA delivery from porous hyaluronic acid hydrogels in mice. Biomaterials. 2014 Jan;35(2):825-35.


36. Cam C, Segura T. Matrix-based gene delivery for tissue repair. Curr Opin Biotechnol. 2013 Oct;24(5):855-63.


35. Dhaliwal A, Oshita V, Segura T. Transfection in the third dimension. Integr Biol (Camb). 2013 Oct;5(10):1206-16.


34. Lam J, Segura T. The modulation of MSC integrin expression by RGD presentation. Biomaterials. 2013 May;34(16):3938-47.


33. Pannier AK, Segura T. Surface- and hydrogel-mediated delivery of nucleic acid nanoparticles. Methods Mol Biol. 2013;948:149-69.


32. Tokatlian T, Cam C, Siegman SN, Lei Y, Segura T. Design and characterization of microporous hyaluronic acid hydrogels for in vitro gene transfer to mMSCs. Acta Biomater. 2012 Nov;8(11):3921-31.


31. Grover GN, Lam J, Nguyen TH, Segura T, Maynard HD. Biocompatible hydrogels by oxime Click chemistry. Biomacromolecules. 2012 Oct 8;13(10):3013-7.


30. Dhaliwal A, Maldonado M, Lin C, Segura T. Cellular cytoskeleton dynamics modulates non-viral gene delivery through RhoGTPases. PLoS One. 2012;7(4):e35046.


29. Zhang J, Tokatlian T, Zhong J, Ng QK, Patterson M, Lowry WE, Carmichael ST, Segura T. Physically associated synthetic hydrogels with long-term covalent stabilization for cell culture and stem cell transplantation. Adv Mater. 2011 Nov 16;23(43):5098-103.


28. Wen J, Anderson SM, Du J, Yan M, Wang J, Shen M, Lu Y, Segura T. Controlled protein delivery based on enzyme-responsive nanocapsules. Adv Mater. 2011 Oct 18;23(39):4549-53.


27. Gojgini S, Tokatlian T, Segura T. Utilizing cell-matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels. Mol Pharm. 2011 Oct 3;8(5):1582-91.


26. Anderson SM, Siegman SN, Segura T. The effect of vascular endothelial growth factor (VEGF) presentation within fibrin matrices on endothelial cell branching. Biomaterials. 2011 Oct;32(30):7432-43.


25. Anderson SM, Shergill B, Barry ZT, Manousiouthakis E, Chen TT, Botvinick E, Platt MO, Iruela-Arispe ML, Segura T. VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF. Integr Biol (Camb). 2011 Sep;3(9):887-96.


24. Lei Y, Rahim M, Ng Q, Segura T. Hyaluronic acid and fibrin hydrogels with concentrated DNA/PEI polyplexes for local gene delivery. J Control Release. 2011 Aug 10;153(3):255-61.


23. Collier JH, Segura T. Evolving the use of peptides as components of biomaterials. Biomaterials. 2011 Jun;32(18):4198-204.


22. Zhang J, Lei Y, Dhaliwal A, Ng QK, Du J, Yan M, Lu Y, Segura T. Protein-polymer nanoparticles for nonviral gene delivery. Biomacromolecules. 2011 Apr 11;12(4):1006-14.


21. Ng QK, Su H, Armijo AL, Czernin J, Radu CG, Segura T. Clustered Arg-Gly-Asp peptides enhances tumor targeting of nonviral vectors. ChemMedChem. 2011 Apr 4;6(4):623-7.


20. Lei Y, Gojgini S, Lam J, Segura T. The spreading, migration and proliferation of mouse mesenchymal stem cells cultured inside hyaluronic acid hydrogels. Biomaterials. 2011 Jan;32(1):39-47.


19. Lei Y, Huang S, Sharif-Kashani P, Chen Y, Kavehpour P, Segura T. Incorporation of active DNA/cationic polymer polyplexes into hydrogel scaffolds. Biomaterials. 2010 Dec;31(34):9106-16.


18. Tokatlian T, Shrum CT, Kadoya WM, Segura T. Protease degradable tethers for controlled and cell-mediated release of nanoparticles in 2- and 3-dimensions. Biomaterials. 2010 Nov;31(31):8072-80.


17. Du J, Yu C, Pan D, Li J, Chen W, Yan M, Segura T, Lu Y. Quantum-dot-decorated robust transductable bioluminescent nanocapsules. J Am Chem Soc. 2010 Sep 22;132(37):12780-1.


16. Lei Y, Ng QK, Segura T. Two and three-dimensional gene transfer from enzymatically degradable hydrogel scaffolds. Microsc Res Tech. 2010 Sep;73(9):910-7.


14. Tokatlian T, Segura T. siRNA applications in nanomedicine. Wiley Interdiscip. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 May-Jun;2(3):305-15


13. Chen TT, Luque A, Lee S, Anderson SM, Segura T, Iruela-Arispe ML. Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. J Cell Biol. 2010 Feb 22;188(4):595-609.


12. Yan M, Du J, Gu Z, Liang M, Hu Y, Zhang W, Priceman S, Wu L, Zhou ZH, Liu Z, Segura T, Tang Y, Lu Y. A novel intracellular protein delivery platform based on single-protein nanocapsules. Nat Nanotechnol. 2010 Jan;5(1):48-53.


11. Anderson SM, Chen TT, Iruela-Arispe ML, Segura T. The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF. Biomaterials. 2009 Sep;30(27):4618-28.


10. Ng QK, Sutton MK, Soonsawad P, Xing L, Cheng H, Segura T. Engineering clustered ligand binding into nonviral vectors: alphavbeta3 targeting as an example. Mol Ther. 2009 May;17(5):828-36.


9. Lei Y, Segura T. DNA delivery from matrix metalloproteinase degradable poly(ethylene glycol) hydrogels to mouse cloned mesenchymal stem cells. Biomaterials. 2009 Jan;30(2):254-65.


8. Adelöw C, Segura T, Hubbell JA, Frey P. The effect of enzymatically degradable poly(ethylene glycol) hydrogels on smooth muscle cell phenotype. Biomaterials. 2008 Jan;29(3):314-26.


7. Segura T, Schmokel H, Hubbell JA. RNA interference targeting hypoxia inducible factor 1alpha reduces post-operative adhesions in rats. J Surg Res. 2007 Aug;141(2):162-70.


6. Segura T, Hubbell JA. Synthesis and in vitro characterization of an ABC triblock copolymer for siRNA delivery. Bioconjug Chem. 2007 May-Jun;18(3):736-45.


5. Bengali Z, Pannier AK, Segura T, Anderson BC, Jang JH, Mustoe TA, Shea LD. Gene delivery through cell culture substrate adsorbed DNA complexes. Biotechnol Bioeng. 2005 May 5;90(3):290-302


4. Segura T, Chung PH, Shea LD. DNA delivery from hyaluronic acid-collagen hydrogels via a substrate-mediated approach. Biomaterials. 2005 May;26(13):1575-84.


3. Segura T, Anderson BC, Chung PH, Webber RE, Shull KR, Shea LD. Crosslinked hyaluronic acid hydrogels: a strategy to functionalize and pattern. Biomaterials. 2005 Feb;26(4):359-71.


2. Segura T, Volk MJ, Shea LD. Substrate-mediated DNA delivery: role of the cationic polymer structure and extent of modification. J Control Release. 2003 Nov 18;93(1):69-84.


1. Segura T, Shea LD. Surface-tethered DNA complexes for enhanced gene delivery. Bioconjug Chem. 2002 May-Jun;13(3):621-9.